In 1927, the beautiful city of Berlin is the gay capital of the world. Ruth, a performer at one of the nightclubs in the city, and her girlfriend, Tillie, are living their lives and enjoying the freedom of the Weimer Republic. They are surrounded by a chosen family that includes drag performers, transgender women, and the prominent physician, Dr. Magnus Hirschfeld. Ruth, Tillie, and their best friends, James and Ernesto spend much of their time at the Institute for Sexual Science, the hub of the queer community in the twenties and early thirties. As the ’20s come to a close, Tillie watches her father, a prominent lawyer, as he becomes more entrenched with the Nazi Party. Working in his law office as his secretary, she meets prominent figures in the Nazi Party, including Joseph Goebbels and Hermann Göring, and becomes increasingly concerned as time passes that there is much more at stake than just her relationship with Ruth, who is also Jewish. Tillie becomes privy to the planning of rallies, the plans the Nazi party is making in order to ensure Nazi victories in major elections, and how the Nazis are taking over Germany one neighborhood at a time.

The novel jumps between the twenties and thirties and the early nineties and a young woman named Thea. Thea is dealing with the onset of her grandmother’s dementia, and discovers secrets hidden away that her grandmother never intended for her to uncover. Alternating between Tillie’s perspective during the ’20s and ’30s as the Weimar Republic slowly gives way to a dictatorship and Thea’s perspective in the ’90s as the secrets of her grandmother’s history come to light, Give My Love to Berlin follows the lives of two gay couples—Tillie and Ruth, and their best friends, James and Ernesto—trying to navigate falling in love, thriving in their community, and coming to terms with the danger they are in just by being who they are.